Unknown

Dataset Information

0

Asymmetric Synthesis of Tetrahydroisoquinoline Derivatives through 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Allyl Alkyl Ketones.


ABSTRACT: A [3 + 2] 1,3-Dipolar cycloaddition of C,N-cyclic azomethine imines with allyl alkyl ketones has been achieved. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. An array of tetrahydroisoquinoline derivatives is generally constructed with good diastereoselectivities and enantioselectivities (up to >25:1 dr, >95% ee). Moreover, the absolute configuration of the product was previously determined by using the quantum electronic circular dichroism calculation and ECD spectrum method.

SUBMITTER: Feng G 

PROVIDER: S-EPMC8156229 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10403559 | biostudies-literature
| S-EPMC2516743 | biostudies-literature
| S-EPMC5811128 | biostudies-other
| S-EPMC5679112 | biostudies-literature
| S-EPMC8809416 | biostudies-literature
| S-EPMC3943969 | biostudies-literature
| S-EPMC9055116 | biostudies-literature
| S-EPMC5839603 | biostudies-literature
| S-EPMC6272743 | biostudies-literature
| S-EPMC9088037 | biostudies-literature