Ontology highlight
ABSTRACT:
SUBMITTER: Bironzo P
PROVIDER: S-EPMC8156829 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Bironzo Paolo P Reale Maria Lucia ML Sperone Tessa T Tabbò Fabrizio F Caglio Andrea A Listì Angela A Passiglia Francesco F Di Maio Massimo M Righi Luisella L Bussolino Federico F Scagliotti Giorgio V GV Novello Silvia S
Cancers 20210517 10
<h4>Background</h4>Tyrosine kinase inhibitors (TKIs) show variable efficacy in epidermal growth factor receptor mutation-positive (EGFR+) NSCLC patients, even in patients harbouring the same mutation. Co-alterations may predict different outcomes to TKIs.<h4>Methods</h4>We retrospectively analysed all consecutive EGFR+ advanced NSCLC treated with first-line TKIs at our Institutions. NGS with a 22 genes clinical panel was performed on diagnostic specimens. PD-L1 expression was also evaluated.<h4> ...[more]