Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study.

ABSTRACT:

Background

Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed.

Aims

To map changes in the KP induced by infant CPB.

Methods

Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry.

Results

Infant CPB results in marked increase in proximal, but not distal metabolites of the KP.

Conclusions

Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.

SUBMITTER: Sabapathy D 

PROVIDER: S-EPMC8157309 | biostudies-literature |

REPOSITORIES: biostudies-literature