Pan-Resistome Insights into the Multidrug Resistance of Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is an important Gram-negative opportunistic pathogen that is responsible for many nosocomial infections. This etiologic agent has acquired, over the years, multiple mechanisms of resistance to a wide range of antimicrobials and the ability to survive in different environments. In this context, our study aims to elucidate the resistome from the A. baumannii strains based on phylogenetic, phylogenomic, and comparative genomics analyses. In silico analysis of the complete genomes of A. baumannii strains was carried out to identify genes involved in the resistance mechanisms and the phylogenetic relationships and grouping of the strains based on the sequence type. The presence of genomic islands containing most of the resistance gene repertoire indicated high genomic pl

SUBMITTER: Rodrigues DLN 

PROVIDER: S-EPMC8157372 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature