Activation of Estrogen Receptor G Protein-Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice.

ABSTRACT:

Background and aims

Estrogen is an important risk factor for cholesterol gallstone disease because women are twice as likely as men to form gallstones. The classical estrogen receptor α (ERα), but not ERβ, in the liver plays a critical role in the formation of estrogen-induced gallstones in female mice. The molecular mechanisms underlying the lithogenic effect of estrogen on gallstone formation have become more complicated with the identification of G protein-coupled receptor 30 (GPR30), an estrogen receptor.

Approach and results

We investigated the biliary and gallstone phenotypes in ovariectomized female GPR30^-/- , ERα^-/- , and wild-type mice injected intramuscularly with the potent GPR30-selective agonist G-1 at 0 or 1 μg/day and fed a lithogenic die

SUBMITTER: Wang HH 

PROVIDER: S-EPMC8157628 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature