Doxorubicin-Loaded MnO₂@Zeolitic Imidazolate Framework-8 Nanoparticles as a Chemophotothermal System for Lung Cancer Therapy.

ABSTRACT: Doxorubicin-loaded MnO₂@zeolitic imidazolate framework-8 (DOX/MnO₂@ZIF-8) nanoparticles, a smart multifunctional therapeutic platform, were prepared for the treatment of lung cancer. The morphology, structure, and redox and photothermal properties of MnO₂@ZIF-8 were characterized by the corresponding methods. The anticancer drug DOX released from the DOX/MnO₂@ZIF-8 nanoparticles was measured. The cell viability of Lewis lung cancer (LLC) cells treated with MnO₂@ZIF-8 or DOX/MnO₂@ZIF-8 nanoparticles was determined using the cell counting kit-8 (CCK-8) method. The cellular uptake of DOX/MnO₂@ZIF-8 nanoparticles into LLC cells was observed using a confocal laser scanning microscope. TUNEL staining was performed to ev

SUBMITTER: Tan C 

PROVIDER: S-EPMC8158835 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature