Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.

ABSTRACT: Although Parkinson disease (PD) causes profound balance impairments, we know very little about how PD impacts the sensorimotor networks we rely on for automatically maintaining balance control. In young healthy people and animals, muscles are activated in a precise temporal and spatial organization when the center of body mass (CoM) is unexpectedly moved that is largely automatic and determined by feedback of CoM motion. Here, we show that PD alters the sensitivity of the sensorimotor feedback transformation. Importantly, sensorimotor feedback transformations for balance in PD remain temporally precise, but become spatially diffuse by recruiting additional muscle activity in antagonist muscles during balance responses. The abnormal antagonist muscle activity remains precisely time-locked t

SUBMITTER: McKay JL 

PROVIDER: S-EPMC8158870 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature