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Cobalt-catalyzed aminocarbonylation of (hetero)aryl halides promoted by visible light.

ABSTRACT: The catalytic aminocarbonylation of (hetero)aryl halides is widely applied in the synthesis of amides but relies heavily on the use of precious metal catalysis. Herein, we report an aminocarbonylation of (hetero)aryl halides using a simple cobalt catalyst under visible light irradiation. The reaction extends to the use of (hetero)aryl chlorides and is successful with a broad range of amine nucleophiles. Mechanistic investigations are consistent with a reaction proceeding via intermolecular charge transfer involving a donor-acceptor complex of the substrate and cobaltate catalyst.

SUBMITTER: Veatch AM

PROVIDER: S-EPMC8159399 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Cobalt-catalyzed aminocarbonylation of (hetero)aryl halides promoted by visible light.

Veatch Alexander M AM Alexanian Erik J EJ

Chemical science 20200622 27

The catalytic aminocarbonylation of (hetero)aryl halides is widely applied in the synthesis of amides but relies heavily on the use of precious metal catalysis. Herein, we report an aminocarbonylation of (hetero)aryl halides using a simple cobalt catalyst under visible light irradiation. The reaction extends to the use of (hetero)aryl chlorides and is successful with a broad range of amine nucleophiles. Mechanistic investigations are consistent with a reaction proceeding <i>via</i> intermolecula ...[more]

PMID: 34123006

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