Ontology highlight
ABSTRACT:
SUBMITTER: Maguire OR
PROVIDER: S-EPMC8159430 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Maguire Oliver R OR Taylor Bethany B Higgins Eleanor M EM Rees Matthew M Cobb Steven L SL Simpkins Nigel S NS Hayes Christopher J CJ O'Donoghue AnnMarie C AC
Chemical science 20200702 29
The acidity of the α-proton in peptides has an essential role in numerous biochemical reactions and underpins their stereochemical integrity, which is critical to their biological function. We report a detailed kinetic and computational study of the acidity of the α-proton in two cyclic peptide systems: diketopiperazine (DKP) and triketopiperazine (TKP). The kinetic acidity (protofugality) of the α-protons were determined though hydrogen deuterium exchange studies in aqueous solutions. The acidi ...[more]