Mixture Cure Models in Oncology: A Tutorial and Practical Guidance.

ABSTRACT: Novel cancer therapies are associated with survival patterns that differ from established therapies, which may include survival curves that plateau after a certain follow-up time point. A fraction of the patient population is then considered statistically cured and subject to the same mortality experience as the cancer-free general population. Mixture cure models have been developed to account for this characteristic. As compared to standard survival analysis, mixture cure models can often lead to profoundly different estimates of long-term survival, required for health economic evaluations. This tutorial is designed as a practical introduction to mixture cure models. Step-by-step instructions are provided for the entire implementation workflow, i.e., from gathering and combining data from

SUBMITTER: Felizzi F 

PROVIDER: S-EPMC8160049 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature