Ontology highlight
ABSTRACT:
SUBMITTER: Pereira B
PROVIDER: S-EPMC8160338 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Pereira Bernard B Chen Christopher T CT Goyal Lipika L Walmsley Charlotte C Pinto Christopher J CJ Baiev Islam I Allen Read R Henderson Laura L Saha Supriya S Reyes Stephanie S Taylor Martin S MS Fitzgerald Donna M DM Broudo Maida Williams MW Sahu Avinash A Gao Xin X Winckler Wendy W Brannon A Rose AR Engelman Jeffrey A JA Leary Rebecca R Stone James R JR Campbell Catarina D CD Juric Dejan D
Nature communications 20210527 1
In patients with metastatic cancer, spatial heterogeneity of somatic alterations may lead to incomplete assessment of a cancer's mutational profile when analyzing a single tumor biopsy. In this study, we perform sequencing of cell-free DNA (cfDNA) and distinct metastatic tissue samples from ten rapid autopsy cases with pre-treated metastatic cancer. We show that levels of heterogeneity in genetic biomarkers vary between patients but that gene expression signatures representative of the tumor mic ...[more]