Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients.

ABSTRACT:

Rationale

Systemic activation of procoagulant and inflammatory mechanisms has been implicated in the pathogenesis of COVID-19. Knowledge of activation of these host response pathways in the lung compartment of COVID-19 patients is limited.

Objectives

To evaluate local and systemic activation of coagulation and interconnected inflammatory responses in critically ill COVID-19 patients with persistent acute respiratory distress syndrome.

Methods

Paired bronchoalveolar lavage fluid and plasma samples were obtained from 17 patients with COVID-19 related persistent acute respiratory distress syndrome (mechanical ventilation > 7 days) 1 and 2 weeks after start mechanical ventilation and compared with 8 healthy controls. Thirty-four host response biomarkers stratified into fi

SUBMITTER: Nossent EJ 

PROVIDER: S-EPMC8160522 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature