Exploiting radical-pair intersystem crossing for maximizing singlet oxygen quantum yields in pure organic fluorescent photosensitizers.

ABSTRACT: Fluorescent photosensitizers (PSs) often encounter low singlet oxygen (¹O₂) quantum yields and fluorescence quenching in the aggregated state, mainly involving the intersystem crossing process. Herein, we successfully realize maximizing ¹O₂ quantum yields of fluorescent PSs through promoting radical-pair intersystem crossing (RP-ISC), which serves as a molecular symmetry-controlling strategy of donor-acceptor (D-A) motifs. The symmetric quadrupolar A-D-A molecule PTP exhibits an excellent ¹O₂ quantum yield of 97.0% with bright near-infrared fluorescence in the aggregated state. Theoretical and ultrafast spectroscopic studies suggested that the RP-ISC mechanism dominated the formation of the triplet for PTP, where effective charge separation and an ultralow singlet-triplet energy gap (0.01 eV) enhanced the ISC process to maximize ¹O₂ generation. Furthermore, in vitro and in vivo experiments demonstrated the dual function of PTP as a fluorescent imaging agent and an anti-cancer therapeutic, with promising potential applications in both diagnosis and theranostics.

SUBMITTER: Wang X 

PROVIDER: S-EPMC8162435 | biostudies-literature |

REPOSITORIES: biostudies-literature