Molecular design of antimicrobial conjugated oligoelectrolytes with enhanced selectivity toward bacterial cells.

ABSTRACT: A series of cationic conjugated oligoelectrolytes (COEs) was designed to understand how variations in molecular dimensions impact the relative activity against bacteria and mammalian cells. These COEs kept a consistent distyrylbenzene framework but differed in the length of linker between the core and the cationic site and the length of substitute on the quaternary ammonium functioned group. Their antimicrobial efficacy, mammalian cell cytotoxicity, hemolytic activity, and cell association were determined. We find that hydrophobicity is a factor that controls the degree of COE association to cells, but in vitro efficacy and cytotoxicity depend on more subtle structural features. COE2-3C-C4butyl was found to be the optimal structure with a minimum inhibitory concentration (MIC

SUBMITTER: Limwongyut J 

PROVIDER: S-EPMC8163332 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature