Unknown

Dataset Information

0

Mechanistic insight into hydroxamate transfer reaction mimicking the inhibition of zinc-containing enzymes.


ABSTRACT: A hydroxamate transfer reaction between metal complexes has been investigated by a combination of experimental and theoretical studies. A hydroxamate-bound cobalt(ii) complex bearing a tetradentate macrocyclic ligand, [CoII(TBDAP)(CH3C(-NHO)O)]+ (1), is prepared by the reduction of a hydroximatocobalt(iii) complex with a biological reductant. Alternatively, 1 is accessible via a synthetic route for the reaction between the cobalt(ii) complex and acetohydroxamic acid in the presence of a base. 1 was isolated and characterized by various physicochemical methods, including UV-vis, IR, ESI-MS, and X-ray crystallography. The hydroxamate transfer reactivity of 1 was examined with a zinc complex, which was followed by UV-vis and ESI-MS. Kinetic and activation parameter data suggest that the hydroxamate transfer reaction occurs via a bimolecular mechanism, which is also supported by DFT calculations. Moreover, 1 is able to inhibit the activity against a zinc enzyme, i.e., matrix metalloproteinase-9. Our overall investigations of the hydroxamate transfer using the synthetic model system provide considerable insight into the final step involved in the inhibition of zinc-containing enzymes.

SUBMITTER: Kwon N 

PROVIDER: S-EPMC8163387 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6136576 | biostudies-literature
| S-EPMC7162195 | biostudies-literature
| S-EPMC3546527 | biostudies-literature
| S-EPMC8372554 | biostudies-literature
| S-EPMC3201791 | biostudies-literature
| S-EPMC5754815 | biostudies-literature
| S-EPMC4618035 | biostudies-literature
| S-EPMC6020523 | biostudies-literature
| S-EPMC5612435 | biostudies-literature
| S-EPMC8827119 | biostudies-literature