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ABSTRACT:
SUBMITTER: Bravin C
PROVIDER: S-EPMC8163447 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Bravin Carlo C Hunter Christopher A CA
Chemical science 20200729 34
Vesicle lipid bilayers have been employed as templates to modulate the product distribution in a dynamic covalent library of Michael adducts formed by mixing a Michael acceptor with thiols. In methanol solution, all possible Michael adducts were obtained in similar amounts. Addition of vesicles to the dynamic covalent library led to the formation of a single major product. The equilibrium constants for formation of the Michael adducts are similar for all of the thiols used in this experiment, an ...[more]