The stromal vascular fraction mitigates radiation-induced gastrointestinal syndrome in mice.

ABSTRACT:

Background

The intestine is particularly sensitive to moderate-high radiation dose and the development of gastrointestinal syndrome (GIS) leads to the rapid loss of intestinal mucosal integrity, resulting in bacterial infiltration, sepsis that comprise patient survival. There is an urgent need for effective and rapid therapeutic countermeasures. The stromal vascular fraction (SVF) derived from adipose tissue is an easily accessible source of cells with angiogenic, anti-inflammatory and regenerative properties. We studied the therapeutic impact of SVF and its action on the intestinal stem cell compartment.

Methods

Mice exposed to the abdominal radiation (18 Gy) received a single intravenous injection of stromal vascular fraction (SVF) (2.5 × 10⁶ cells), obtained by

SUBMITTER: Bensemmane L 

PROVIDER: S-EPMC8164266 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature