Dataset Information

Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children.

ABSTRACT:

Background

Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies.

Methods

We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan.

Results

Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13-2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26-7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25-2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05-6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2-3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31-2.84, P = 0.001) relative to those with 0-1 risk genotype.

Conclusion

HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children.

SUBMITTER: Zhou J

PROVIDER: S-EPMC8164710 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Association of <i>HMGA2</i> Polymorphisms with Glioma Susceptibility in Chinese Children.

Zhou Jingying J Wang Pan P Zhang Ran R Huang Xiaokai X Dai Hanqi H Yuan Li L Ruan Jichen J

Pharmacogenomics and personalized medicine 20210525

<h4>Background</h4>Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. <i>HMGA2</i> is a proto-oncogene with increased expression in various malignancies.<h4>Methods</h4>We explored the association of <i>HMGA2</i> polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). <i>HMGA2</i> single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan. ...[more]

PMID: 34079335

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