Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation.

ABSTRACT:

Background

Lymphatic abnormalities play a role in effusions in individuals with a Fontan circulation. Recent results using near-infrared fluorescence imaging disclosed an increased contraction frequency of lymphatic vessels in Fontan patients compared to healthy controls. It is proposed that the elevated lymphatic pumping seen in the Fontan patients is necessary to maintain habitual interstitial fluid balance. Hyperthermia has previously been used as a tool for lymphatic stress test. By increasing fluid filtration in the capillary bed, the lymphatic workload and contraction frequency are increased accordingly. Using near-infrared fluorescence imaging, the lymphatic functional reserve capacity in Fontan patients were explored with a lymphatic stress test.

Methods

Fontan patie

SUBMITTER: Mohanakumar S 

PROVIDER: S-EPMC8165731 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature