Ontology highlight
ABSTRACT:
SUBMITTER: Han Z
PROVIDER: S-EPMC8166871 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Han Zhu Z Zhang Weizhi W Ning Wanshan W Wang Chenwei C Deng Wankun W Li Zhidan Z Shang Zehua Z Shen Xiaofei X Liu Xiaohui X Baba Otto O Morita Tsuyoshi T Chen Lu L Xue Yu Y Jia Da D
Nature communications 20210531 1
Autophagy can selectively target protein aggregates, pathogens, and dysfunctional organelles for the lysosomal degradation. Aberrant regulation of autophagy promotes tumorigenesis, while it is far less clear whether and how tumor-specific alterations result in autophagic aberrance. To form a link between aberrant autophagy selectivity and human cancer, we establish a computational pipeline and prioritize 222 potential LIR (LC3-interacting region) motif-associated mutations (LAMs) in 148 proteins ...[more]