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Trace and major elements in food supplements of different origin: Implications for daily intake levels and health risks.

ABSTRACT: As the use of food supplements increases, voices are being raised questioning the safety of these products. As a contribution to understanding the trace and major elemental composition of food supplements and their potential health risks, this study presents concentrations of 71 elements in 138 supplements, categorised into synthetic products and three groups of products with natural ingredients. Concentrations were converted into average daily doses (ADDs) and compared to tolerable daily intakes (TDIs). For elements where we found significant ADDs relative to the TDI a comparison was also made to the normal dietary intake. Our main findings are that: 1) Most elements display highly variable concentrations in food supplements; more so than in normal foodstuff; 2) For ten of the analysed elements some products rendered ADDs > 50 % of the TDI. Half of the elements were essential (Fe, Mn, Se, Mo, Zn), and as such motivated in food supplements. The other half (As, Pb, Cd, Al, Ni) represent non-essential and highly toxic elements, where the occurrence in food supplements ought to be viewed as contamination. Although none of these toxic metals were declared on any product's table of content, several products gave high ADDs - in several cases even exceeding the TDIs; 3) The risk of reaching high ADDs for the toxic elements is strongly associated with products that contain marine ingredients (e.g. algae, mussels etc), and to some degree products of terrestrial plant-based origin. The health of consumers would benefit if food regulatory frameworks were updated to better address the risks of food supplements occasionally being contaminated with different toxic metals, for example by setting maximum permissible concentrations for a longer list of elements.

SUBMITTER: Augustsson A

PROVIDER: S-EPMC8166911 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Simple Summary Coastal systems often serve as sinks for toxic elements, and seasonality has been responsible for many changes in the physical and chemical parameters of waters and sediments, leading to geochemical alterations in aquatic systems and the alteration of element uptake rates in organisms. Diopatra neapolitana worms were collected from five sites of the Ria de Aveiro lagoon in the autumn, winter, spring, and summer of 2018/2019 and were tested to check for differences in the biochemical responses (cell damage, antioxidant enzymes, biotransformation enzymes, and energy-related parameters) among seasons and sites. In general, the results demonstrated that enzyme activities were higher in spring and summer due to high temperatures and element bioaccumulation. Energy-related parameters presented with higher levels in spring and autumn, which was mainly due to element bioaccumulation. Oxidative damage was higher during winter and was related to salinity and decreases in temperature. This study demonstrated that abiotic factors influence the geochemistry of elements and that both significantly affect organism performance in low-contamination systems, such as the Ria de Aveiro lagoon. This knowledge is important to understand how ecological and economically relevant species such as D. neapolitana respond to environmental changes. Abstract Polychaetes are known to be good bioindicators of marine pollution, such as inorganic contamination. Major and trace elements are commonly present in sediment and may be accumulated by polychaetes such as the tubiculous Diopatra neapolitana. In this study, D. neapolitana individuals were collected in the autumn, winter, spring, and summer of 2018/2019 from the Ria de Aveiro lagoon (western Portugal) to understand how seasonality influences element accumulation. The impact of the interaction of seasonality and elements on oxidative status, energy metabolism, and oxidative damage was also assessed. The obtained results showed that the activity of the antioxidant enzymes catalase, glutathione S-transferases, and non-protein thiol levels were higher in summer and that superoxide dismutase, lipid peroxidation, and electron transport system activity increased in winter. The lowest glycogen levels were observed during spring, and protein carbonylation was the highest during autumn. These results could mainly be related to high temperatures and the bioaccumulation of Al, As, Mn, and Zn. Energy-related parameters increased during spring and autumn, mainly due to the bioaccumulation of the same elements during spring and summer. Lipid damage was higher during winter, which was mainly due to salinity and temperature decreases. Overall, this study demonstrates that seasonality plays a role in element accumulation by polychaetes and that both impact the oxidative status of D. neapolitana.

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Trace and major elements in food supplements of different origin: Implications for daily intake levels and health risks.

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