Ontology highlight
ABSTRACT:
SUBMITTER: Bartosch AMW
PROVIDER: S-EPMC8166914 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Bartosch Anne Marie W AMW Mathews Rick R Mahmoud Marwa M MM Cancel Limary M LM Haq Zahin S ZS Tarbell John M JM
Scientific reports 20210531 1
This study aimed to clarify the role of glypican-1 and PECAM-1 in shear-induced nitric oxide production in endothelial cells. Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein endothelial cells and nitric oxide was measured using a fluorescent reporter dye. Glypican-1 pulling for 30 min stimulated nitric oxide production while PECAM-1 pulling did not. However, PECAM-1 downstream activation was necessary for the glypican-1 for ...[more]