Ontology highlight
ABSTRACT:
SUBMITTER: Sincennes MC
PROVIDER: S-EPMC8167170 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Sincennes Marie-Claude MC Brun Caroline E CE Lin Alexander Y T AYT Rosembert Tabitha T Datzkiw David D Saber John J Ming Hong H Kawabe Yoh-Ichi YI Rudnicki Michael A MA
Nature communications 20210531 1
Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of two acetylation sites on PAX7 that positively regulate its transcriptional activity. Lack of PAX7 acetylation reduces DNA binding, specifically to the homeobox motif. The acetyltransferase MYST1 stimulated by Acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD +, are identified as direct regulators of PAX7 acetylation and as ...[more]