Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes.
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ABSTRACT:
SUBMITTER: Hamilton BA
PROVIDER: S-EPMC8168460 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes.
Hamilton Bradley A BA Wright J Fraser JF
Frontiers in immunology 20210517
Host immune responses that limit durable therapeutic gene expression and cause clinically significant inflammation remain a major barrier to broadly successful development of adeno-associated virus (AAV)-based human gene therapies. In this article, mechanisms of humoral and cellular immune responses to the viral vector are discussed. A perspective is provided that removal of pathogen-associated molecular patterns in AAV vector genomes to prevent the generation of innate immune danger signals fol ...[more]
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2025-03-13 | GSE256350 | GEO