Co-expression Network Revealed Roles of RNA m⁶A Methylation in Human β-Cell of Type 2 Diabetes Mellitus.

ABSTRACT: RNA m⁶A methylation plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). RNA modifications and RNA-modifying regulators have recently emerged as critical factors involved in β-cell function and insulin resistance, including "writers," "erasers," and "readers." However, their key roles in regulating gene expression in T2DM remain unclear. The construction of co-expression network could provide a cue to resolve this complex regulatory pathway. We collected the transcriptome datasets of β-cell in diabetic patients, calculated the partial correlation coefficient, excluded the influence from control variables of diabetes related genes, and identified the genes significantly co-expressed with m⁶A regulators. A total of 985 genes co-expressed with

SUBMITTER: Chen C 

PROVIDER: S-EPMC8168466 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature