Associations of actigraphic sleep and circadian rest/activity rhythms with cognition in the early phase of Alzheimer's disease.

ABSTRACT:

Study objectives

To compare sleep and circadian rest/activity rhythms (RARs), quantified by standard and novel actigraphic metrics, between controls and participants with mild cognitive impairment (MCI), and to examine the cross-sectional relationships between these measures and cognition.

Methods

Actigraphy data were collected in 179 older individuals (mean age = 72.6 years) with normal cognition (n = 153) and MCI (n = 26). Sleep parameters (e.g. sleep efficiency), and standard nonparametric RARs (e.g. interdaily stability) were generated. Functional principal component analysis (fPCA) was used to generate three novel RAR metrics (fPC1, fPC2, and fPC3). Cognitive composite scores reflecting episodic memory and executive function were derived using factor analy

SUBMITTER: Alfini A 

PROVIDER: S-EPMC8168567 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature