Selection of Antiobesity Medications Based on Phenotypes Enhances Weight Loss: A Pragmatic Trial in an Obesity Clinic.

ABSTRACT:

Objective

Little is known about the predictors of response to obesity interventions.

Methods

In 450 participants with obesity, body composition, resting energy expenditure, satiety, satiation, eating behavior, affect, and physical activity were measured by validated studies and questionnaires. These variables were used to classify obesity phenotypes. Subsequently, in a 12-month, pragmatic, real-world trial performed in a weight management center, 312 patients were randomly assigned to phenotype-guided treatment or non-phenotype-guided treatment with antiobesity medications: phentermine, phentermine/topiramate, bupropion/naltrexone, lorcaserin, and liraglutide. The primary outcome was weight loss at 12 months.

Results

Four phenotypes of obesity were identified in 383 o

SUBMITTER: Acosta A 

PROVIDER: S-EPMC8168710 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature