Time-varying effect of sex on prognosis of lung adenocarcinoma surgical patients in China.

ABSTRACT:

Background

Little is known about the prognostic advantage of sex for pulmonary adenocarcinoma among Chinese patients. In this study, we aimed to investigate the true sex differences in prognosis by adjusting for confounders and to explore whether the differences were time-varying.

Methods

We identified 4438 lung adenocarcinoma patients who underwent surgery at a regional Cancer Center of China from 2008 to 2016, retrospectively. Sex, age group, smoking history, year of diagnosis and pathological stage were collected. Time-dependent Cox regression models with inverse probability of treatment weighting (IPTW) based on propensity score were used to assess the effect of sex and account for confounders. Landmark analyses were conducted to assess survival before, and after, five y

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8169287 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature