Persistent Herpes Simplex Virus Type 1 Infection of Enteric Neurons Triggers CD8⁺ T Cell Response and Gastrointestinal Neuromuscular Dysfunction.

ABSTRACT: Behind the central nervous system, neurotropic viruses can reach and persist even in the enteric nervous system (ENS), the neuronal network embedded in the gut wall. We recently reported that immediately following orogastric (OG) administration, Herpes simplex virus (HSV)-1 infects murine enteric neurons and recruits mononuclear cells in the myenteric plexus. In the current work, we took those findings a step forward by investigating the persistence of HSV-1 in the ENS and the local adaptive immune responses against HSV-1 that might contribute to neuronal damage in an animal model. Our study demonstrated specific viral RNA transcripts and proteins in the longitudinal muscle layer containing the myenteric plexus (LMMP) up to 10 weeks post HSV-1 infection. CD3⁺CD8⁺INFγ<

SUBMITTER: Brun P 

PROVIDER: S-EPMC8169984 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature