Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial.

ABSTRACT:

Objective

To assess the effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery.

Design

Phase III, randomised, double blind, placebo controlled trial.

Setting

34 centres in France, December 2017 to March 2019.

Participants

1222 adults (>50 years) requiring major non-cardiac surgery with an expected duration of more than 90 minutes. The anticipated time frame for recruitment was 24 months.

Interventions

Participants were randomised to receive either dexamethasone (0.2 mg/kg immediately after the surgical procedure, and on day 1) or placebo. Randomisation was stratified on the two prespecified criteria of cancer and thoracic procedure.

Main outcomes measures

The primary outcome was a composite of postoperative

SUBMITTER: Asehnoune K 

PROVIDER: S-EPMC8171383 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature