A Fluorinated Ionic Liquid-Based Activatable ¹⁹F MRI Platform Detects Biological Targets.

ABSTRACT: ¹⁹F magnetic resonance imaging (¹⁹F MRI) is a promising technique for in vivo molecular imaging and clinical diagnosis, benefiting from its negligible background and unlimited tissue penetration depth. However, the development of ¹⁹F probes with good water solubility and versatile functions for bioresponsive and practical applications remains a challenge. Here, we report fluorinated ion liquids (ILs) as a new type of fluorine agents and build a fluorinated ionic liquid-based activatable ¹⁹F MRI platform (FILAMP), which relies on the phase transition of ILs. Upon exposure to environmental stimulation, coating polymer dissolves or degrades to release the fluorinated ILs payload, which rapidly enhances ¹⁹F signal. This "turn-on" re

SUBMITTER: Zhu X 

PROVIDER: S-EPMC8171808 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature