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Alterations in Chromatin Folding Patterns in Cancer Variant-Enriched Loci.


ABSTRACT: In this study, we focus on the following question: do genomic regions enriched in cancer variant mutations have significantly different chromatin folding patterns? We utilize publicly available Hi-C data to characterize chromatin folding patterns in healthy (GM12878) and cancer (K562) cells based on status of A/B compartmentalization and random vs non-random chromatin physical interactions. We then perform statistical testing to assess if chromatin folding patterns in cancer variant-enriched loci are significantly different from non-enriched loci. Our results indicate that loci with cancer variant status have significantly altered (FDR < 0.05) chromatin folding patterns.

SUBMITTER: Perez-Rathke A 

PROVIDER: S-EPMC8172279 | biostudies-literature |

REPOSITORIES: biostudies-literature

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