Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma.
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ABSTRACT:
SUBMITTER: De Martino M
PROVIDER: S-EPMC8173136 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma.
De Martino Mara M Padilla Oscar O Daviaud Camille C Wu Cheng-Chia CC Gartrell Robyn D RD Vanpouille-Box Claire C
Frontiers in oncology 20210520
Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improved the care of several adult cancers with previously dismal prognoses, monotherapy with IT in GBM has shown minimal response in first recurrence. Recent discoveries in lymphatics and evaluation of blood brain barrier offer insight to improve the use of ITs and ...[more]
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