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Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature.

ABSTRACT: Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product.

SUBMITTER: Tamboli Y

PROVIDER: S-EPMC8173612 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature.

Tamboli Yasinalli Y Kashid Bharat B BB Yadav Ram Prasad RP Rafeeq Mohammad M Yeole Ravindra R Merwade Arvind Y AY

ACS omega 20210519 21

Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product. ...[more]

PMID: 34095685

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