Tryptophan levels associate with incident cardiovascular disease in chronic kidney disease.

ABSTRACT:

Background

Non-traditional risk factors like inflammation and oxidative stress play an essential role in the increased cardiovascular disease (CVD) risk prevalent in chronic kidney disease (CKD). Tryptophan catabolism by the kynurenine pathway (KP) is linked to systemic inflammation and CVD in the general and dialysis population. However, the relationship of KP to incident CVD in the CKD population is unknown.

Methods

We measured tryptophan metabolites using targeted mass spectrometry in 92 patients with a history of CVD (old CVD); 46 patients with no history of CVD and new CVD during follow-up (no CVD); and 46 patients with no CVD history who developed CVD in the median follow-up period of 2 years (incident CVD).

Results

The three groups are well-matched in age, gend

SUBMITTER: Konje VC 

PROVIDER: S-EPMC8173620 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature