Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.
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ABSTRACT:
SUBMITTER: Lin A
PROVIDER: S-EPMC8173803 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.
Lin Andrea A Mack Jasmine A JA Bruggeman Brittany B Jacobsen Laura M LM Posgai Amanda L AL Wasserfall Clive H CH Brusko Todd M TM Atkinson Mark A MA Gitelman Stephen E SE Gottlieb Peter A PA Gurka Matthew J MJ Mathews Clayton E CE Schatz Desmond A DA Haller Michael J MJ
Diabetes 20210225 5
Previously, we demonstrated low-dose antithymocyte globulin (ATG) and granulocyte colony-stimulating factor (GCSF) immunotherapy preserved C-peptide for 2 years in a pilot study of patients with established type 1 diabetes (<i>n</i> = 25). Here, we evaluated the long-term outcomes of ATG/GCSF in study participants with 5 years of available follow-up data (<i>n</i> = 15). The primary end point was area under the curve (AUC) C-peptide during a 2-h mixed-meal tolerance test. After 5 years, there we ...[more]
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