Assessment of Foveal Avascular Zone and Macular Vascular Plexus Density in Children With Unilateral Amblyopia: A Systemic Review and Meta-Analysis.

ABSTRACT: Purpose: To examine the quantitative measurements of OCTA in children with amblyopia using the meta-analysis methodology. Methods: PubMed, Embase, and Cochrane library were searched for available papers up to March 2021. Weighted mean differences (WMD) were used to compare the retina parameters between the eyes with amblyopia and the contralateral eyes or healthy control eyes. Results: Twelve studies were included. When considering the parafovea, the microvessel density was reduced in amblyopic eyes compared with healthy control eyes in the superficial capillary plexus (SCP) in 6 × 6 volume scan (WMD = -2.12, 95%CI: -3.24, -0.99) but not SCP in 3 × 3 volume scan (WMD = -1.43, 95%CI: -2.96, 0.11). In the deep capillary plexus (DCP), amblyopia did not decrease vessel den

SUBMITTER: Gao L 

PROVIDER: S-EPMC8175854 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature