Browse
Submit Data
Databases
API
Help

Dataset Information

12 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Zwitterionic liquid crystalline polythiophene as an antibiofouling biomaterial.

ABSTRACT: To address a key challenge of conjugated polymers in biomedical applications having poor antifouling properties that eventually leads to the failure and reduced lifetime of bioelectronics in the body, herein we describe the design, synthesis, and evaluation of our newly designed multifunctional zwitterionic liquid crystalline polymer PCBTh-C8C10, which is facilely synthesized using oxidative polymerization. A conjugated polythiophene backbone, a multifunctional zwitterionic side chain, and a mesogenic unit are integrated into one segment. By DSC and POM characterization, we verify that the introduction of 3,5-bis(2-octyl-1-dodecyloxy)benzene as a mesogenic unit into the polythiophene backbone allows the formation of the liquid crystalline mesophase of the resulting polymer. We also demonstrate that the PCBTh-C8C10 coated surface exhibits good conductivity, stability, hydrophilicity, and remarkable antibiofouling properties against protein adsorption, cell growth, and bacteria attachment. This new zwitterionic liquid crystalline polymer having good antibiofouling features will be widely recognized as a promising biomaterial that is applicable in implantable organic bioelectronics via inhibiting the foreign body response. A deep understanding of structure-property relationships of zwitterionic conjugated polymers has also been provided in this study.

SUBMITTER: Xu J

PROVIDER: S-EPMC8176281 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Zwitterionic Porous Conjugated Polymers as a Versatile Platform for Antibiofouling Implantable Bioelectronics.

Project description:Here, we describe the design, synthesis, and evaluation of two kinds of multifunctional zwitterionic linear poly(carboxybetaine thiophene) (PCBTh) and porous poly(carboxybetaine thiophene-co-9,9'-bifluoreneylidene) (PCBTh-coBF) polymers, which can be facilely synthesized using Yamamoto and Suzuki polycondensation, respectively. The integrations of zwitterionic polymer-based biomaterials that consist of conjugated polymer backbones, multifunctional zwitterionic side chains, and distorted units are designed and studied to address a key challenge of conjugated polymers in biomedical applications: biofouling phenomena that eventually lead to the failure and reduced lifetime of bioelectronics in the body. The introduction of a twisting unit into the polymer backbone allows us to tune the porosity, morphology, optical properties, and efficiency of antibiofouling features of resulting polymers. The PCBTh-coBF coated surface exhibits good conductivity, stability, hydrophilicity, and antibiofouling properties against protein adsorption, cell growth, and bacteria attachment, which may be useful for chronic in vivo bioelectronics applications by minimizing the foreign body response.

| S-EPMC7266170 | biostudies-literature

A Readily Scalable, Clinically Demonstrated, Antibiofouling Zwitterionic Surface Treatment for Implantable Medical Devices.

Project description:Unlike growth on tissue, microbes can grow freely on implantable devices with minimal immune system intervention and often form resilient biofilms that continuously pump out pathogenic cells. The efficacy of antibiotics used to treat infection is declining due to increased rates of pathogenic resistance. A simple, one-step zwitterionic surface modification is developed to significantly reduce protein and microbial adhesion to synthetic materials and demonstrate the successful modification of several clinically relevant materials, including recalcitrant materials such as elastomeric polydimethylsiloxane. The treated surfaces exhibit robust adhesion resistance against proteins and microorganisms in both static and flow conditions. Furthermore, the surface treatment prevents the adhesion of mammalian fibroblast cells while displaying no cytotoxicity. To demonstrate the clinical efficacy of the novel technology in the real-world, a surface-treated, commercial silicone foley catheter is developed that is cleared for use by the U.S. Food and Drug Administration (K192034). 16 long-term catheterized patients received surface-treated catheters and completed a Patient Global Impression of Improvement (PGI-I) questionnaire. 10 out of 16 patients described their urinary tract condition post implantation as "much better" or "very much better" and 72% (n = 13) of patients desire to continue using the surface-treated catheter over conventional latex or silicone catheters.

| S-EPMC9153982 | biostudies-literature

Integrated zwitterionic conjugated poly(carboxybetaine thiophene) as a new biomaterial platform.

Project description:An integrated zwitterionic conjugated polymer-based biomaterial platform was designed and studied to address some of the key challenges of conjugated polymers in biomedical applications. This biomaterial platform consists of conjugated polymer backbones and multifunctional zwitterionic side chains. Zwitterionic materials gain electrical conductivity and interesting optical properties through conjugated polymer backbones, and non-biocompatible conjugated polymers obtain excellent antifouling properties, enhanced electrical conductivity, functional groups of bioconjugation and response to environmental stimuli via multifunctional zwitterionic side chains. This platform can potentially be adapted to a wide range of applications (e.g. bioelectronics, tissue engineering and biofuel cell), which require high performance conducting materials with excellent antifouling/biocompatibility at biointerfaces.

| S-EPMC5592746 | biostudies-literature

Porous Laser-Scribed Graphene Electrodes Modified with Zwitterionic Moieties: A Strategy for Antibiofouling and Low-Impedance Interfaces.

Project description:Laser-scribed graphene electrodes (LSGEs) are promising platforms for the development of electrochemical biosensors for point-of-care settings and continuous monitoring and wearable applications. However, the frequent occurrence of biofouling drastically reduces the sensitivity and selectivity of these devices, hampering their sensing performance. Herein, we describe a versatile, low-impedance, and robust antibiofouling interface based on sulfobetaine-zwitterionic moieties. The interface induces the formation of a hydration layer and exerts electrostatic repulsion, protecting the electrode surface from the nonspecific adsorption of various biofouling agents. We demonstrate through electrochemical and microscopy techniques that the modified electrode exhibits outstanding antifouling properties, preserving more than 90% of the original signal after 24 h of exposure to bovine serum albumin protein, HeLa cells, and Escherichia coli bacteria. The promising performance of this antifouling strategy suggests that it is a viable option for prolonging the lifetime of LSGEs-based sensors when operating on complex biological systems.

| S-EPMC10835659 | biostudies-literature

Self-cleaning and antibiofouling enamel surface by slippery liquid-infused technique.

Project description:We aimed to create a slippery liquid-infused enamel surface with antibiofouling property to prevent dental biofilm/plaque formation. First, a micro/nanoporous enamel surface was obtained by 37% phosphoric acid etching. The surface was then functionalized by hydrophobic low-surface energy heptadecafluoro-1,1,2,2-tetra- hydrodecyltrichlorosilane. Subsequent infusion of fluorocarbon lubricants (Fluorinert FC-70) into the polyfluoroalkyl-silanized rough surface resulted in an enamel surface with slippery liquid-infused porous surface (SLIPS). The results of water contact angle measurement, diffuse-reflectance Fourier transform infrared spectroscopy, and atomic force microscope confirmed that the SLIPS was successfully constructed on the enamel surface. The antibiofouling property of the SLIPS was evaluated by the adsorption of salivary protein of mucin and Streptococcus mutans in vitro, as well as dental biofilm formation using a rabbit model in vivo. The results showed that the SLIPS on the enamel surface significantly inhibited mucin adhesion and S. mutans biofilm formation in vitro, and inhibited dental plaque formation in vivo.

| S-EPMC4867434 | biostudies-other

A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.

Project description:The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.

| S-EPMC5322155 | biostudies-other

Electrically Reconfigurable Liquid Crystalline Mirrors.

Project description:Reconfigurable optical materials are critical to realizing light control in eyewear or architectural windows. Here, we report on the electrical reconfiguration of the selective reflection of cholesteric liquid crystals (LCs). The distinctive responses detailed here are enabled by the preparation of a structurally chiral polymer stabilizing network that enforces anchoring of a low-molar-mass liquid crystalline media with positive dielectric anisotropy. The pitch of the reflective optical elements is directly regulated by a dc field, resulting in red or blue reflection wavelength tuning or broadening. The use of the positive dielectric LC host in concert with optimization of the material preparation conditions allows for reorientation of the LC molecules to achieve an optically clear state (homeotropic orientation) by the application of an ac field. In this way, the selective reflection of the optical elements can be moved, widened, and turned on and off. The electro-optic characteristics of these materials are another step forward to enabling the use of these materials in optics and photonics.

| S-EPMC6641427 | biostudies-literature

Durable liquid-crystalline vitrimer actuators.

Project description:Vitrimer-based liquid-crystalline elastomers (LCEs) exhibit great advantages over the traditional LCEs due to their inherent processability to realize monodomain alignment and construction of LCE actuators with complex 3D structures in a robust way. Though exciting progress has been made, how to achieve a proper balance between processability and actuation durability/stability remains a big challenge. Here, we report a strategy to mitigate the conflict between processability and actuation stability by reducing the catalyst content in an epoxy/acid LCE vitrimer system. With a relatively low catalyst content (0.25 mol% to carboxyl group), monodomain LCEs with large actuation strain (∼95%) and excellent actuation stability (the actuation strain is completely maintained after 100 heating-cooling cycles and more than 90% of the initial strain is retained even after 500 cycles) could be easily prepared. Moreover, the monodomain LCEs can still be readily realigned or directly reconfigured into complex reversible 3D actuators.

| S-EPMC6427948 | biostudies-literature

Spontaneous mirror symmetry breaking in benzil-based soft crystalline, cubic liquid crystalline and isotropic liquid phases.

Project description:Benzil (diphenylethane-1,2-dione), which is a long known example for an achiral molecule crystallizing in a chiral space group, can also show mirror symmetry breaking in the fluid state if it is suitably functionalized. For some of the new benzil derivatives even three different subsequent mirror symmetry broken soft matter states with a chiral conglomerate structure can be observed. One is an isotropic liquid, the second one a cubic liquid crystal with a complex network structure and the third is a soft crystalline solid. Chirality develops by helical self-assembly combined with dynamic network formation, thus allowing macroscopic chirality synchronization. These achiral molecules, combining a transiently chiral bent core with multiple alkyl chains, provide a unique link between the mirror symmetry breaking phenomena observed for polycatenar and bent-core mesogens. The homogeneously chiral networks are of interest for application as chiral materials, and as templates for chiral recognition, separation and enantioselective catalysis.

| S-EPMC7446726 | biostudies-literature

Liquid crystalline cellulose-based nematogels.

Project description:Physical properties of composite materials can be pre-engineered by controlling their structure and composition at the mesoscale. However, approaches to achieving this are limited and rarely scalable. We introduce a new breed of self-assembled nematogels formed by an orientationally ordered network of thin cellulose nanofibers infiltrated with a thermotropic nematic fluid. The interplay between orientational ordering within the nematic network and that of the small-molecule liquid crystal around it yields a composite with highly tunable optical properties. By means of combining experimental characterization and modeling, we demonstrate submillisecond electric switching of transparency and facile responses of the composite to temperature changes. Finally, we discuss a host of potential technological uses of these self-assembled nematogel composites, ranging from smart and privacy windows to novel flexible displays.

| S-EPMC5562421 | biostudies-other

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data