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Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

ABSTRACT: Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC₅₀ values of 1.5-7.7 nM.

SUBMITTER: Otsuki K

PROVIDER: S-EPMC8176625 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

Otsuki Kouharu K Li Wei W Miura Kasumi K Asada Yoshihisa Y Huang Li L Chen Chin-Ho CH Lee Kuo-Hsiung KH Koike Kazuo K

Journal of natural products 20200930 11

Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity wi ...[more]

PMID: 32997496

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