Dataset Information

End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts.

ABSTRACT:

Introduction

End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we compared characteristics and outcomes of ESKD and non-ESKD patients admitted with COVID-19 to a large safety-net hospital.

Methods

We evaluated 759 adults (45 with ESKD) hospitalized with COVID-19 in Spring of 2020. We examined clinical characteristics, laboratory measures and clinical outcomes. Logistic regression analyses were performed to investigate the associations between ESKD status and outcomes.

Results

73% of ESKD and 47% of non-ESKD patients identified as Black (p = 0.002). ESKD patients were older and had higher rates of comorbidities. Admission ferritin was approximately 6-fold higher in ESKD patients. During hospitalization, the rise in white blood cell count, lactate dehydrogenase, ferritin and C-reactive protein, and the decrease in platelet count and serum albumin were all significantly greater in ESKD patients. The in-hospital mortality was higher for ESKD [18% vs. 10%; multivariable adjusted odds ratio 1.5 (95% CI, 0.48-4.70)], but this did not reach statistical significance.

Conclusions

Among hospitalized COVID-19 patients, ESKD patients had more co-morbidities and more robust inflammatory response than non-ESKD patients. The odds ratio point estimate for death was higher in ESKD patients, but the difference did not reach statistical significance.

SUBMITTER: Kamel MH

PROVIDER: S-EPMC8177422 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts.

Kamel Mohamed Hassan MH Mahmoud Hassan H Zhen Aileen A Liu Jing J Bielick Catherine G CG Mostaghim Anahita A Lin Nina N Chitalia Vipul V Ilori Titilayo T Waikar Sushrut S SS Upadhyay Ashish A

PloS one 20210604 6

<h4>Introduction</h4>End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we compared characteristics and outcomes of ESKD and non-ESKD patients admitted with COVID-19 to a large safety-net hospital.<h4>Methods</h4>We evaluated 759 adults (45 with ESKD) hospitalized with COVID-19 in Spring of 2020. We examined clinical characteristics, laboratory measures and clinical outcomes. Logistic regression analyses were performed to investiga ...[more]

PMID: 34086775

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Dataset Information

End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts.

Introduction

Methods

Results

Conclusions

Publications

End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts.

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