Effect of herbal extracts on peripheral nerve regeneration after microsurgery of the sciatic nerve in rats.

ABSTRACT:

Background

Recent experimental studies using herbal extracts have shown the possibility of peripheral nerve regeneration. This study aimed to investigate the effects of herbal extracts on peripheral nerve regeneration in a rat sciatic nerve injury model.

Methods

A total of 53 rats were randomly assigned to a control group or one of four experimental groups. In all rats, the sciatic nerve was completely severed and microscopic epineural end-to-end neurorrhaphy was performed. Normal saline (2 mL) was topically applied to the site of nerve repair in the control group, whereas four different herbal extracts - 2 mL each of Astragalus mongholicus Bunge, Coptis japonica (Thunb.) Makino, Aconitum carmichaelii Debeaux, or Paeonia lactiflora Pall. - were topically applied to the site

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC8178854 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature