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Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides.

ABSTRACT: We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones. The reaction tolerates a variety of functional groups under mild reaction conditions, which complements the current methods. The utility of this work was demonstrated by facile late-stage functionalization of commercial drugs.

SUBMITTER: Sun D

PROVIDER: S-EPMC8179603 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides.

Sun Deli D Ma Guobin G Zhao Xinluo X Lei Chuanhu C Gong Hegui H

Chemical science 20210219 14

We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones. The reaction tolerates a variety of functional groups under mild reaction conditions, which complements the current methods. The utility of this work was demonstrated by facile late-stage functionalization of commercial drugs. ...[more]

PMID: 34168777

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