Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages.

ABSTRACT:

Background

Macrophages are important cells of the innate immune system and contribute to a variety of physiological and pathophysiological responses. Monovalent and divalent ion channels have been studied in macrophage function, and while much research is still required, a role for these channels is beginning to emerge in macrophages. In addition to the plasma membrane, ion channels are also found in intracellular membranes including mitochondrial, lysosomal and nuclear membranes. While studying the function of plasma membrane located large conductance voltage- and calcium-activated potassium channels (BK channels) in a macrophage cell line RAW264.7, we became aware of the expression of these ion channels in other cellular locations.

Methods

Immunofluorescence and Western bl

SUBMITTER: Selezneva A 

PROVIDER: S-EPMC8180476 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature