The role of heterocyclic aromatic amines in colorectal cancer: the evidence from epidemiologic studies.

ABSTRACT: Since Dr. Sugimura's discovery of heterocyclic aromatic amines (HAA) in broiled fish, many epidemiological studies have been conducted to investigate their role in human cancers, often focusing on colorectal cancer. The difficulty in measuring HAA exposure from meat and fish intake in these studies has resulted in inconsistent findings. Because studying individuals who may be particularly susceptible to the carcinogenic effects of HAA might facilitate the demonstration of a link with cancer, multiple studies have focused on individuals with the high activity phenotype for CYP1A2 and/or NAT2, the two main metabolic enzymes involved in the bioactivation of HAA. These investigations have also yielded inconsistent results. Two recent large pooled analyses of colorectal cancer studies have help

SUBMITTER: Le Marchand L 

PROVIDER: S-EPMC8183058 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature