A multicenter prospective randomized controlled trial of cardiac resynchronization therapy guided by invasive dP/dt.

ABSTRACT:

Background

No periprocedural metric has demonstrated improved cardiac resynchronization therapy (CRT) outcomes in a multicenter setting.

Objective

We sought to determine if left ventricular (LV) lead placement targeted to the coronary sinus (CS) branch generating the best acute hemodynamic response (AHR) results in improved outcomes at 6 months.

Methods

In this multicenter randomized controlled trial, patients were randomized to guided CRT or conventional CRT. Patients in the guided arm had LV dP/dt_max measured during biventricular (BIV) pacing. Target CS branches were identified and the final LV lead position was the branch with the best AHR and acceptable threshold values. The primary endpoint was the proportion of patients with a reduction in LV end-syst

SUBMITTER: Sohal M 

PROVIDER: S-EPMC8183864 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature