Targeted resequencing showing novel common and rare genetic variants increases the risk of asthma in the Chinese Han population.

ABSTRACT:

Background

Although studies have identified hundreds of genetic variants associated with asthma risk, a large fraction of heritability remains unexplained, especially in Chinese individuals.

Methods

To identify genetic risk factors for asthma in a Han Chinese population, 211 asthma-related genes were first selected based on database searches. The genes were then sequenced for subjects in a Discovery Cohort (284 asthma patients and 205 older healthy controls) using targeted next-generation sequencing. Bioinformatics analysis and statistical association analyses were performed to reveal the associations between rare/common variants and asthma, respectively. The identified common risk variants underwent a validation analysis using a Replication Cohort (664 patients and 650 cont

SUBMITTER: Liu J 

PROVIDER: S-EPMC8183914 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature