Involvement of Cerebellar Neural Circuits in Active Avoidance Conditioning in Zebrafish.

ABSTRACT: When animals repeatedly receive a combination of neutral conditional stimulus (CS) and aversive unconditional stimulus (US), they learn the relationship between CS and US, and show conditioned fear responses after CS. They show passive responses such as freezing or panic movements (classical or Pavlovian fear conditioning), or active behavioral responses to avoid aversive stimuli (active avoidance). Previous studies suggested the roles of the cerebellum in classical fear conditioning but it remains elusive whether the cerebellum is involved in active avoidance conditioning. In this study, we analyzed the roles of cerebellar neural circuits during active avoidance in adult zebrafish. When pairs of CS (light) and US (electric shock) were administered to wild-type zebrafish, about half of the

SUBMITTER: Koyama W 

PROVIDER: S-EPMC8184220 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature