Dataset Information

Tumor microenvironment immune-related lncRNA signature for patients with melanoma.

ABSTRACT:

Background

The incidence of malignant melanoma accounts for only approximately 5% of skin malignant tumors, however, it accounts for 75% of its mortality. Long-chain non-coding RNA (lncRNA) has a wide range of functional activities. Disorders of lncRNAs may lead to the occurrence and development of melanoma, and may also be related to immunotherapy.

Methods

The transcriptomic data of primary and metastatic melanoma patients and 331 immune-related genes were downloaded from skin cutaneous melanoma (SKCM) in the The Cancer Genome Atlas (TCGA) database. On this basis, 460 immunologically relevant lncRNAs were identified by constructing a co-expression network of immunogenic genes and lncRNAs in primary and metastatic melanoma patients. Prognostic genes were screened using univariate Cox regression analysis. ROC analysis was performed to evaluate the robustness of the prognostic signature.

Results

Univariate correlation analysis showed that only 3 of the 23 immune-related lncRNAs were at high risk and the rest were at low risk. Signatures of 7 immune-related lncRNAs were identified by multivariate correlation analysis. The clinical correlation analysis showed that the 7 immune-related lncRNAs were associated with the clinical stage of primary and metastatic melanoma. Principal component analysis (PCA) showed that only 7 immune-related lncRNA signals divided tumor patients into high-risk and low-risk groups, while the low-risk group was enriched in the immune system process M13664 and immune response M19817 sets. PPI interaction network analysis showed that 11 G protein-coupled receptors and 6 corresponding ligands in the 2 gene sets affected the tumor microenvironment and were negatively related to the risk of the 7 immune-related lncRNAs. The tumor microenvironment immune cell infiltration analysis also supported the finding that anti-tumor immunity in the low-risk group was stronger than in the high-risk group.

Conclusions

These results indicate that characteristics of the 7 immune-related lncRNAs have prognostic value for melanoma patients and can be used as potential immunotherapy targets.

SUBMITTER: Guo JH

PROVIDER: S-EPMC8184426 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Tumor microenvironment immune-related lncRNA signature for patients with melanoma.

Guo Jia-Hui JH Yin Shan-Shan SS Liu Hua H Liu Feng F Gao Feng-Hou FH

Annals of translational medicine 20210501 10

<h4>Background</h4>The incidence of malignant melanoma accounts for only approximately 5% of skin malignant tumors, however, it accounts for 75% of its mortality. Long-chain non-coding RNA (lncRNA) has a wide range of functional activities. Disorders of lncRNAs may lead to the occurrence and development of melanoma, and may also be related to immunotherapy.<h4>Methods</h4>The transcriptomic data of primary and metastatic melanoma patients and 331 immune-related genes were downloaded from skin cu ...[more]

PMID: 34164491

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Dataset Information

Tumor microenvironment immune-related lncRNA signature for patients with melanoma.

Background

Methods

Results

Conclusions

Publications

Tumor microenvironment immune-related lncRNA signature for patients with melanoma.

Similar Datasets

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