Fronto-striatal structures related with model-based control as an endophenotype for obsessive-compulsive disorder.

ABSTRACT: Recent theories suggest a shift from model-based goal-directed to model-free habitual decision-making in obsessive-compulsive disorder (OCD). However, it is yet unclear, whether this shift in the decision process is heritable. We investigated 32 patients with OCD, 27 unaffected siblings (SIBs) and 31 healthy controls (HCs) using the two-step task. We computed behavioral and reaction time analyses and fitted a computational model to assess the balance between model-based and model-free control. 80 subjects also underwent structural imaging. We observed a significant ordered effect for the shift towards model-free control in the direction OCD > SIB > HC in our computational parameter of interest. However less directed analyses revealed no shift towards model-free control in OCDs. Nonetheless

SUBMITTER: Kasal MI 

PROVIDER: S-EPMC8185095 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature