Association between NF-kB polymorphism and age-related macular degeneration in a high-altitude population.

ABSTRACT:

Objective

To investigate the association between the nuclear factor kappa B (NF-kB) gene polymorphism and age-related macular degeneration (AMD) in a high-altitude population.

Methods

Fifty-five patients with AMD and 57 control subjects were recruited from the Qinghai Provincial People's Hospital, China. Genomic DNA was extracted from the blood sample of each participant. Four NF-kB polymorphisms (rs3774959, rs3774932, rs3774937, and rs230526) were genotyped using a MassARRAY system. The genotype and allele frequencies were compared between the case and control groups using the chi-squared test or Fisher's exact test.

Results

There was no significant difference in sex, age, hypertension, diabetes, blood lipid level or smoking and drinking status between the AMD and co

SUBMITTER: Xin Y 

PROVIDER: S-EPMC8186772 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature